[Recurrent urinary tract infections: prevention of recurrence with intravesical instillations of chondroitin sulfate and hyaluronic acid.] / Infecciones urinarias de repetición: prevención de recidivas con instilaciones intravesicales de condroitin sulfato sódico y ácido hialurónico.

OBJECTIVE: The aim of our study is to demonstrate that intravesical administration of the association chondroitin sulfate (CS) and hyaluronic acid (HA), according to our treatment schedule, is a benefit for women with recurrent urinary tract infections (RUTI), not only from a clinical point of view, but also reducing recurrences. METHODS: This is a study of 28 women diagnosed with RUTI, with a positive culture, and compatible symptoms;frethey underwent treatment according to the protocol of intravesical instillations of the combination CS 2%-1 gr + HA 1.6%-800 mg. To evaluate the effectiveness of the treatment, symptoms improvement, reduction of the number of episodes of urinary tract infection and quality of life were considered. RESULTS: In our series, we can observe an improvement of the quality of life assessed by PG-I, 66% after 12 months. It was seen that 55.6% of the patient's urine cultures became negative, while 44.4% had episodes of urinary infection, but with lower baseline symptoms intensity. DISCUSSION: Patients included in the protocol of instillation improved significantly their quality of life; in addition, to a considerable extent new urinary infections were not presented, being milder when they presented.

Infecciones urinarias de repetición: prevención de recidivas con instilaciones intravesicales de condroitin sulfato sódico y ácido hialurónico / Recurrent urinary tract infections: prevention of recurrence with intravesical instillations of chondroitin sulfate and hyaluronic acid

OBJETIVO: El objetivo de nuestro estudio es demostrar, que la administración intravesical de la asociación condroitin sulfato sódico (CS) y ácido hialurónico (AH) según nuestro esquema de tratamiento, supone un beneficio en mujeres pre/post menopáusicas con infecciones urinarias de repetición (IUR), no sólo desde el punto de vista clínico, sino que también disminuyen las recurrencias. MÉTODOS: Se presenta un estudio con 28 mujeres diagnosticadas de IUR con cultivo positivo y síntomas compatibles, siguieron tratamiento según protocolo de instilaciones intravesicales de la combinación CS 2%-1 gr + AH 1,6%-800 mg (IALURIL®). Para comprobar la eficacia del tratamiento se evaluó: mejoría de síntomas, reducción del número de episodios de infección urinaria y la calidad de vida. RESULTADOS: En nuestra serie se apreció una mejoría de la calidad de vida, valorada por la escala de impresión de mejoría global del paciente (PG-I), a los 12 meses del 66%. Se apreció que el 55,6% (15/27) de las pacientes negativizaron sus cultivos, mientras que el 44,4% (12/27) presentaron un solo episodio de infección urinaria pero con menor intensidad de síntomas que al inicio del estudio. CONCLUSIONES: Los pacientes incluidos en el protocolo de instilación mejoraron de forma significativa su calidad de vida, además en un porcentaje considerable no se presentaron nuevas infecciones urinarias; en los casos que se presentaron estas fueron menos frecuentes y afectaron menos el estado general de las pacientes que pretratamiento

OBJECTIVE: The aim of our study is to demonstrate that intravesical administration of the association chondroitin sulfate (CS) and hyaluronic acid (HA), according to our treatment schedule, is a benefit for women with recurrent urinary tract infections (RUTI), not only from a clinical point of view, but also reducing recurrences. METHODS: This is a study of 28 women diagnosed with RUTI, with a positive culture, and compatible symptoms; frethey underwent treatment according to the protocol of intravesical instillations of the combination CS 2%-1 gr + HA 1.6%-800 mg. To evaluate the effectiveness of the treatment, symptoms improvement, reduction of the number of episodes of urinary tract infection and quality of life were considered. RESULTS: In our series, we can observe an improvement of the quality of life assessed by PG-I, 66% after 12 months. It was seen that 55.6% of the patient`s urine cultures became negative, while 44.4% had episodes of urinary infection, but with lower baseline symptoms intensity. DISCUSSION: Patients included in the protocol of instillation improved significantly their quality of life; in addition, to a considerable extent new urinary infections were not presented, being milder when they presented